Rat Anti-Mouse CD3e-LE/AF Antibody MBS673153 from MyBioSource.com

Product Specs
ItemRat Anti-Mouse CD3e-LE/AF Antibody
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS673153
Quantity0.5 mg
ApplicationsFlow Cytometry, Immunohistochemistry, Immunoprecipitation
Conjugate/TagUnconjugated
FormatLow Endotoxin, Azide - Free (LE/AF)
ReactivityMouse
TargetCD3 epsilon
IsotypeIgG2b kappa
CloneC363.29B (YCD3-1)
HostRat
ImmunogenMouse CD3 epsilon (Mr 25 kD)
CD3 epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chain ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains.^1, 2 CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The monoclonal antibody C363.29B recognizes an epitope on the 25kD epsilon chain of the CD3/TCR complex.^1 In the presence of Fc receptor-bearing accessory cells, soluble C363.29B can activate primed and naïve T cell in vitro. Immobilized C363.29 monoclonal antibody can also activate both normal T lymphocytes and cloned T cell lines provided the appropriate accessory signals are present.^1, 3, 4 The monoclonal antibody is cytolytic, easily used for cell surface staining and a good immunoprecipitating antibody.^1
ClonalityMonoclonal